It can be, just depends on how fast you’ll be polling, how your code is implemented, how much of the data you want, etc…
Those sensors output quite a bit of data, and 50 is a lot…you’ll probably need several microcontrollers, each being able to intake 5-10 sensors’ data and a sophisticated interrupt/polling arrangement.
Your next step is probably to grab an Artemis or two (or esp32s), a mux, several qwiic cables, and some TMF8821 sensors and begin testing & trying to max out the setup…then buy however many needed to complete your project