Sensor placement and multiplexing frequency

Hi, currently redesigning the HVAC system on an older vehicle, building a control system with an esp32 and currently deciding on the sensors to use. I’m leaning towards the BME688 and am wanting to place a handful of them hidden thoughout the cars cabin, and use the mux breakout for multiplexing. I’m wondering if say I were to throw one behind the headliner would the gas / humidity sensors be of any use, and how is the polling rate effected by having half a dozen monitering all at once.

If you are planning to use I2C communications, consider that connections longer than a few cm can be very problematic. I2C was designed for chip to chip communications on a single PCB.