If activation time of the 64 channels is not critical, you could send 8 bytes + address over any standard serial rf module, where the individual bits of the 8 bytes sent represent the on-off status of the 64 channels. If this is ok, almost any PIC or AVR will do the trick. As an example, I did a project that allows a group of devices to communicate among themselves by sending or receiving packets of up to 52 bytes. Project details are available at the following link:
I could select address from the transmitter and send a 4 byte or 8 byte code (through their channell inputs) and use a Microcontroller to decode the binary input.