It will need a low noise amplifier with a good gain (at least 25 to 30dB). If you power the LNA separately I think it should be ok to design the circuit similar to how you would with a passive.
I am very interested in using this combination for a keyring scale gps logger. I have experience with AVR micros and intend to link the gps to a small avr, maybe mega8.
I would be interested in any progress made with this combination of gps and antannea and any references that would help in the successful pcb layout of the gps and antannea, and any required amplification.