“The FT245R is a USB to parallel FIFO interface” - [Src
So depending on your application needs, maybe. If you need a USB to serial adapter, then no it is not the same thing.
The FTDI [FT232R is a USB to serial adapter. It makes a great quick and easy replacement of where you would of traditionally used a MAX232 serial line driver/transceiver to connect to a serial port.
The FTFI FT245R is a simple USB to parallel interface with very basic buffering (First In, First Out). If you have a larger microcontroller with lots of pins and is fast itself, then the F245R could possibly provide faster bulk data transfers. That could be a benefit for say a high resolution digital camera, or a MP3 player with lots of storage.](http://www.ftdichip.com/Products/FT232R.htm)](http://www.ftdichip.com/Products/FT245R.htm)